One granulocyte infusion done!

Whew...

I was told earlier in the day that my donated granulocytes would be infused about 8:00 pm on Friday. Visiting hours end at 8:00 pm, but I was worried about how this might go so I asked Greg to stay, at least for the first fifteen minutes. Luckily our nurse was willing to ignore that he was in the room.

I needed to receive Benadryl and Tylenol before the transfusion to minimize a reaction to receiving blood products from someone who is not me. Granulocytes are much more likely to cause a reaction than either platelets or red blood cells, and I already had one reaction to platelets, so that made sense. My nurse said she preferred to wait for the product to be on the floor before giving me my pre-meds, because blood products are often late. In addition, granulocytes have the shortest life after being harvested of any of the blood products, so I knew we had to get them in ASAP. The infusion instructions said to infuse over 2-4 hours. The slower the infusion, the lesser chance of reaction, but of course the longer time of the cells not in my body working, but potentially dying in the bag. I negotiated with my nurse and we agreed on a three hour infusion.

They weren't here at 7:30. Or 8:00. My nurse was calling over and over to see when they'd arrive. They had to be couriered from the donation site (not sure where) and then irradiated at the Froedtert Versiti, and then they'd be delivered to the floor. My nurse was also worried about time and discussed with Versiti that when they arrived on the Froedtert/MCW campus, they'd call her and she'd start the pre-meds. 

I was getting more and more nervous and worried about this life-saving donation being completely useless if it was too late. We waited. Finally about 9:15 (Greg was still here), my nurse heard from Versiti that they had the donation and were treating it. I got pre-medicated. But the donation didn't arrive in half an hour. My nurse checked and said half an hour before transfusion is the minimum, so I'd still be okay. We waited. Greg and I were both falling asleep. And they they arrived at about 11:00. Unfortunately they expired at 1:10 am, so they had to be infused over the shortest time (two hours).

Greg waited and the nurse stayed in my room for fifteen minutes to monitor my vitals and make sure I didn't have any classic reactions. I didn't feel anything. I was just tired. The fifteen minutes were up, and  Greg and my nurse both left. I settled in to do some visualization of the cells traveling to each of my fungal spots and working their magic. (By the way, if you haven't watched Cells At Work, it's all really good, but the neutrophil animations are especially accurate and relevant--just know that I was given a TON of neutrophils so it was even more chaos.)

Not even fifteen minutes after the nurse and Greg left, my nose started running like a faucet. Then I was sneezing like crazy. At the same time, the stye in my left eye was throbbing and swelling so much that I couldn't open my left eye. As that continued (I had to find another box of Puffs Plus), the entire front of my face was hurting. My upper teeth ached so bad that I had to remove my night mouth guard. Still more sneezing and nose pouring out stuff. My nurse checked on me and asked if there was anything she could do for me. I didn't know what that would even be, and I certainly didn't want to stop the infusion (or even pause it, since we had no wiggle room on the expiration time). I told her I wasn't having trouble breathing or itching or any other typical reaction. I wondered if it was really the neutrophils working that quickly.

Neutrophils are the most abundant white blood cell (in healthy people). Unlike the branch of the immune system that has memory to prior exposures and makes specific antibodies to remember specific exposures (thus the science behind an immunization--which takes awhile to take effect), the granulocytes (neutrophils, basophils, eosinophils) are the immediate response. They are non-specific, so if something that is foreign enters, they hit it right away. When I had mucositis following my stem cell transplant, I only needed a few thousand neutrophils to show up before I started feeling better. In fact, I felt better even before they were measurable in my blood. But remember this transfusion was loaded with neutrophils.

So they flooded every part of my body that had something foreign present. Thus the sinuses (I'm assuming that there was/is fungus in there), my eye stye, maybe the random bacteria in my gums since I haven't had my teeth cleaned in so long? And my fungal skin lesions. Every single one of them started to throb. I'd been told I had four spots on my back, but couldn't see them. I felt them. I felt it in my biopsy site, where my first spot appeared, on my upper lip, and several on the soles of my feet. It was excruciating! I tried to visualize over the pain. I felt that this HAD to mean that this treatment was working and doing exactly what it should. I made it through the two hour infusion. But the pain didn't go away. In fact, about an hour after the infusion completed, it got worse. (My Tylenol had worn off). I couldn't open my eyes (throbbing stye plus photosensitivity) but actually asked the nurse for help with my pain. I didn't think I could take Tylenol again, and so she suggested oxycodone. I hate opioids with a passion, but I remembered how they helped me get through four miserable nights with mucositis and that I didn't get addicted. I agreed. But the doctors on call wanted to use Tylenol instead. Finally, after not napping all day Friday, and staying up through the infusion and aftermath, sometime between 3:00 and 4:00 am, I fell asleep.

When I woke up this morning the throbbing in my sinuses, eye and teeth was gone. As soon as the morning Tylenol wore off, the pain in the fungal skin spots returned, in addition to "flu-like symptoms" including chills and body aches. I needed more sleep. I took more Tylenol and slept more. When I was due for my next Tylenol dose, it had to be delayed due to taking Tylenol before the anti-fungal. So I hung out in fetal position and made it through. I am happy that the Tylenol seems to be doing the trick.

But how amazingly cool is this all? To actually FEEL the attack of the neutrophils all over my body? I talked to Dr. Swanson about it to make sure I wasn't over-simplifying things and she said it made sense. Furthermore, she examined my spots and showed me the proof. The flat marks now had true heads, filled with pus, which is the dead neutrophils after their work is done.

I am in awe--again of my donor who must have been at Versiti much longer than they'd expected, and will be in the future. But I'm also just blown away by the human body and how, when it works, it works!

I don't think this has taken care of everything, but it's made a good start. And I have to say that I'm also really very happy that I don't have to do it again tonight already. I'm hoping for a few good night's sleep and maybe decreasing pain without medication. And then I'll be ready to do it all over again on Monday (and Tuesday and Thursday, apparently). Thank you, amazing donor!